Well, this calculation will involve some hand-waving, because who knows what the pharmacokinetics do as you head upwards like that. Ve have found that Ivermectin is very effective, what was reported in vitro in the Australia study carried out in early April, we have evidenced it when treating people with COVID Can a qualified professional please comment on Dr.
At the same time I was good in math.
Also google the 1. It does distribute strongly out into tissue, though, and that combined with its intrinsically high activity against the roundworms does the job. A paper was also published in Ann Emerg Med reporting on ivermectin overdoses. But I get your point……. Bill Gates has promised to build us seven vaccine production plants from money he made when Microhard stopped supporting Windows XP! The world today has 6.
But first, what is collagen?
Now if we do a really great job on new vaccines, health care, reproductive health services, we lower that by perhaps 10 or 15 percent. As president, he listened to physicians who had great success. I go back quite a ways with this compound, back to my graduate school days when several folks in my old research group were trying to complete a total synthesis of the compound.
FYI everyone — Only proper nouns e. Thank you. I am not getting much of a result from Duckduckgo.
An apparent enrichment in tissue might by relevant here. This comment was so helpful in policing the proper bounds of discourse!!! I still have some hopes for repurposed drugs against the coronavirus, but not really in this case. A related group of compounds, without the carbohydrates on the side, are the milbemycins. Update: see here for more on Ivermectin PK as regards coronavirus therapy.
There have been some human studies for efficacy, but all I can find out is that a preliminary read showed no reduction of viral load in the infected patients, and there seems to have been no update.
Please provide the statement from the FDAabout the doctors self medicating with it ended up in hospitals. But since denguevirus is also a single-strand positive-sense RNA virus, Ivermectin has come up as a possible coronavirus drug, mechanism or not.
But who am I? Hello I am curious, in which countries is Ivermectin available without a prescription? So what is this compound doing in the news with the coronavirus? Thank you! I am not scientist or doctor but Yes! This Brazilian doctor says that the disease has fases and she treats every patient differently depending in the fase.
Told you it was potent! The dose could probably be higher, if you asked me. Everyone knows that the oleandrose side chains and spiroketal forms a dimeric metal coordination site that serves as an ionophore for zinc! I believe — had they been done, hundreds of lives could have been saved here and hundreds of thousands of lives could have been saved worldwide. The oxygens coordinate Lithium ions better, which is good for many folks in this blog who seem to experience a manic episode. We have to chastise nerdowells? In case you get to the second fase respiratory symptoms the hydroxycloroquine inhibits the over imune response To the virus.
Vaccines were the goal. Johns Hopkins has ramped up the dosing protocol a bit. Did you start with that amount with that frequency or did you initially use a different potency and frequency? People I know get it over-the-counter in the Dominican Republic where it is used against the covid; maybe purchasable in Mexico.
The carbohydrate part is two oleandrose units in a row; I think that this is the most famous occurrence of that otherwise obscure sugar. I hope the teacher gives you a cookie for properly chastising the nerdowells in the back of the class.
The art of compiling remedies: books, classifications and techniques. from kitchen to study?
I trust in Derek but my triple check says the right answer is nanomolar, not pico. If this is real, it should definitely show in the other trials that are underway. Trump ordered large batches of HCQ but sent it to Brazil after he was ridiculed and challenged on his lack of medical training.
The drug is effective against a wide of parasites and arthropods in general- looks, mites, lice, heartworms and fleas in dogs, parasitic worms in pasture animals, as an ingredient in ant baits, and more. Talk to cardiologists. Derek would like you to read Dr. She separated the patients into phases and sub-phases and applied different remedies in each phase, curing them. Clinical unimportant Rub Covid; it is ongoing with due in early July, and 2.
Update: there are actually nine trials showing at Clinicaltrials. Yep… roughly 30 ng divided by MW bit under is around 40 picomol per ml, therefore around 40 nanomol per l, therefore around 40 nmol. Well, there is a four arm study underway in Egypt, three of the arms including Ivermectin combined with another drug, with a completion date estimated to be in the year It is body to take 10 years to recruit 80 Recip Think as if you were going to capitalize water or oxygen within a sentence.
There is a Hydroxychloroquine arm, a Hydroxychloroquine with Azithromycin arm and a And by itself arm. Feldman: Ah yes, did you bring the um … the specimen of your um … and so on, and so on? The thing oral Ivermectin is that it is effective against things like the river blindless parasite at down low doses: one 12mg or 18mg dose every few months. Or where could I find required Over 3 billion people have been medicated with ivermectin since with minimal effects from the drug itself.
Update: there is a reportusing data from a company that has a real-time hospitalization database, of a retrospective matched-control set of coronavirus patients receiving Ivermectin versus those that did not. Alas, success was not the goal. As those letters to Antiviral Research note, ivermectin will start to hit other targets as you jack up the doses. I wonder what is the rationale for the protocol then…. Obvious error breeds misinformation. For that reason, the FDA has been warning people not to take the drug for the coronavirus.
Comments on “what’s up with ivermectin?”
Its ion-channel mechanism of action against parasites has no application to viruses. Yes, 35 nM! A concern, then, is that some of these effects reported in vivo e. And it appears to have unimportant reduced the average of children per family. Puede darle una vista a esta liga?
The Ivermectin is just 12 mg days 1 and 2,…. Sort of a diverser four-armed study. After that the anticoagulants with antibiotics and cortisone reduces the severity if Recip last fase of the disease. But it has been shown several times to have activity in cell assays against Dengue infection and to reduce viral lo in the mosquito vectors see this oral and references thereinalthough the reasons for this are still unknown. Yes, but did they test it in the and of Zinc? None of the drug names required should be capitalized.
The thing is, if you crank up the concentration, probably a lot of stuff will Rub any look virus in vitro relevant XKCD. This analysis showed a pronounced effect in favor of Ivermectin, which is quite interesting. More on this as data come in. The protocol from your link suggests 0. As you might imagine, getting that thing in that position and even down keeping it there was very annoying. Nonetheless, there is said to be a clinical trial in France getting underway investigating the drug, and just the other day one went up at Clinicaltrials. Dear Mr Lowe, may I call you Derek, I recently found your article about ivermectin dated 11th May, only 4 months after the COVID 19 pandemic began and read it with interest plus the numerous comments that have been added since.
That paper is also a good review of the attempts at repurposing the body in the antiviral space.
One of their more famous ones, I think. Merck, I should note, has donated the drug for those purposes ever since the late s. My God, man, our national defense and current search for a cure to Chinese coronoviremia depends on nerds who do well. A group at Monash Univ. One would have to hope that the compound concentrates ificantly in the site s of action — really, really ificantly.